Researchers take one step closer to curing HIV by eliminating infection human tissue in mice.
Researchers from Lewis Katz School of Medicine said,”The next stage would be to repeat the study in primates, a more suitable animal model where HIV infection induces disease, in order to further demonstrate the elimination of HIV-1 DNA.
“Here, we demonstrate the feasibility and efficiency of excising the HIV-1 provirus in three different animal models,” reported the researchers.
“To our knowledge, this study is the first to demonstrate the effective excision of HIV-1 proviral DNA from the host genome in pre-clinical animal models [using this method].”
Our eventual goal is a clinical trial in human patients,” Khalili (co-senior study investigator) added. They noted some ‘practical’ problems but are hoping to test the method on humans by 2020.